Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process el 1648 0.0 1.0 0.599 0.268
biological_process ka 1648 0.0 1.0 0.121 0.211
biological_process rf 1648 0.0 1.0 0.127 0.214
cellular_component ct 184 0.0 0.911 0.171 0.254
cellular_component el 184 0.001 0.925 0.306 0.24
cellular_component ka 184 0.0 0.906 0.167 0.252
cellular_component rf 184 0.0 0.905 0.17 0.254
disease ct 1456 0.0 0.999 0.042 0.135
disease el 1456 0.0 1.0 0.167 0.224
disease ka 1456 0.0 0.993 0.04 0.131
disease rf 1456 0.0 0.999 0.042 0.135
genetic_interaction el 1606 0.0 0.999 0.408 0.308
genetic_interaction ka 1606 0.0 0.987 0.299 0.241
genetic_interaction rf 1606 0.0 0.999 0.399 0.311
molecular_function ct 473 0.0 0.995 0.278 0.306
molecular_function el 473 0.0 0.998 0.405 0.286
molecular_function ka 473 0.0 0.987 0.271 0.302
molecular_function rf 473 0.0 0.995 0.278 0.306
pathway ct 555 0.0 1.0 0.274 0.342
pathway el 555 0.0 0.86 0.192 0.285
pathway ka 555 0.0 0.27 0.024 0.045
pathway rf 555 0.0 0.86 0.184 0.279
phenotype ct 1358 0.0 0.998 0.072 0.163
phenotype el 1358 0.0 0.998 0.253 0.195
phenotype ka 1358 0.0 0.992 0.07 0.168
phenotype rf 1358 0.0 0.998 0.072 0.164
protein_interaction ct 1657 0.0 1.0 0.07 0.163
protein_interaction el 1657 0.0 0.933 0.065 0.157
protein_interaction ka 1657 0.0 0.156 0.007 0.018
protein_interaction rf 1657 0.0 0.926 0.066 0.154

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 1676 0.0 1.0 0.166 0.271
integration_mean_by_presence el 1676 0.0 0.979 0.13 0.153
integration_mean_by_presence ka 1676 0.0 0.954 0.049 0.136
integration_mean_by_presence rf 1676 0.0 0.923 0.055 0.123
mean ct 1676 0.0 1.0 0.148 0.252
mean el 1676 0.0 0.979 0.119 0.142
mean ka 1676 0.0 0.949 0.041 0.126
mean rf 1676 0.0 0.91 0.05 0.115

CDF plots of non integrated kernels

CDF plots of integrated kernels